Clinical phenotypes and heath-related quality of life of COPD patients in a rural setting in Malaysia – a cross-sectional study

Chai, Chee Shee and Sumastika, Mos and Ng, Diana Leh-Ching and Goh, Greta Miranda Kim Choo and Su, Anselm Ting and Muhammad Amin, Ibrahim and Aisya Natasya, Musa and Tan, Seng Beng and Pang, Yong Kek and Liam, Chong Kin (2020) Clinical phenotypes and heath-related quality of life of COPD patients in a rural setting in Malaysia – a cross-sectional study. BMC pulmonary medicine, 20 (254). pp. 1-9. ISSN 1471-2466

[img] PDF
Clinical phenotypes and heath-relatedquality of life of COPD patients in a ruralsetting in Malaysia–a cross-sectional study.pdf

Download (224kB)
Official URL: https://doi.org/10.1186/s12890-020-01295-4

Abstract

Background: The Spanish chronic obstructive pulmonary disease (COPD) guideline phenotypes patients according to the exacerbation frequency and COPD subtypes. In this study, we compared the patients’ health-related quality of life (HRQoL) according to their COPD phenotypes. Methods: This was a cross-sectional study of COPD patients who attended the outpatient clinic of the Serian Divisional Hospital and Bau District Hospital from 23th January 2018 to 22th January 2019. The HRQoL was assessed using modified Medical Research Council (mMRC), COPD Assessment Test (CAT), and St George’s Respiratory Questionnaire for COPD (SGRQ-c). Results: Of 185 patients, 108 (58.4%) were non-exacerbators (NON-AE), 51 (27.6%) were frequent exacerbators (AE), and the remaining 26 (14.1%) had asthma-COPD overlap (ACO). Of AE patients, 42 (82.4%) had chronic bronchitis and only 9 (17.6%) had emphysema. Of the 185 COPD patients, 65.9% had exposure to biomass fuel and 69.1% were ex- or current smokers. The scores of mMRC, CAT, and SGRQ-c were significantly different between COPD phenotypes (p < 0.001). There were significantly more patients with mMRC 2–4 among AE (68.6%) (p < 0.001), compared to those with ACO (38.5%) and NON-AE (16.7%). AE patients had significantly higher total CAT (p=0.003; p < 0.001) and SGRQ-c (both p < 0.001) scores than those with ACO and NON-AE. Patients with ACO had significantly higher total CAT and SGRQ-c (both p< 0.001) scores thanthose with NON-AE. AE patients had significantly higher score in each item of CAT and component of SGRQ-c compared to those with NON-AE (all p < 0.001), and ACO [(p = 0.003–0.016; p=<0.001–0.005) except CAT 1, 2 and 7. ACO patients had significantly higher score in each item of CAT and component of SGRQ-c (p=<0.001–0.040; p < 0.001) except CAT 2 and activity components of SGRQ-c. Conclusions: The HRQoL of COPD patients was significantly different across different COPD phenotypes. HRQoL was worst in AE, followed by ACO and NON-AE. This study supports phenotyping COPD patients based on their exacerbation frequency and COPD subtypes. The treatment of COPD should be personalised according to these two factors.

Item Type: Article
Uncontrolled Keywords: Chronic obstructive pulmonary disease, Clinical phenotypes, Health-related quality of life, Exacerbators, Asthmaoverlap, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Shee
Date Deposited: 30 Sep 2020 05:55
Last Modified: 30 Sep 2020 05:56
URI: http://ir.unimas.my/id/eprint/32047

Actions (For repository members only: login required)

View Item View Item