Detection of spleen abscesses facilitates diagnosis of melioidosis in Malaysian children

Mohan, Anand and Manan, Kamilah and Tan, Lee See and Tan, Yee Chin and Chin, Shi Tying and Ahmad, Rohani and Hamli, Qairul Irwan and Chuah, Teik-Beng and Chien, Su Lin and Teck Lau, Peter Sie and Podin, Yuwana and Ooi, Mong How (2020) Detection of spleen abscesses facilitates diagnosis of melioidosis in Malaysian children. International Journal of Infectious Diseases, 98. pp. 59-66. ISSN 1201-9712

[img] PDF
Detection of spleen abscesses facilitates diagnosis of melioidosis in Malaysian children1.pdf

Download (261kB)
Official URL:


Objectives Melioidosis is associated with extremely high case fatality ratios. The aim of this study was to determine whether detection of abdominal visceral abscesses can facilitate diagnosis of melioidosis in children. Methods We conducted a retrospective analysis of all children who had liver and/or spleen abscesses on abdominal ultrasonography admitted to Bintulu Hospital in Sarawak, Malaysia, from January 2014 until December 2018. Results Fifty-three children had liver and/or spleen abscesses. Spleen abscesses were present in 48 (91%) cases; liver abscesses in 15 (28%). Melioidosis was confirmed by culture in 9 (17%) children; small occult splenic abscesses were present in all cases. In 78% of these cases, the lesions were detected before any positive culture (or serology) results were available. Four (8%) children had bacteriologically-confirmed tuberculosis. Two (4%) had Staphylococcus aureus infection. Of the remaining 38 (72%) culture-negative cases, 36 (95%) had clinical and imaging characteristics similar to that of children with culture-confirmed melioidosis and improved with empirical melioidosis antibiotic therapy. Conclusions A large number of children in Bintulu Hospital in Sarawak, Malaysia, were found to have spleen abscesses. Melioidosis was the most common etiology identified in these children. Abdominal ultrasonography is extremely useful in facilitating the diagnosis of pediatric melioidosis.

Item Type: Article
Uncontrolled Keywords: Spleenabscess, Liverabscess, Melioidosis, Tuberculosis, Children, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > RB Pathology
Divisions: Academic Faculties, Institutes and Centres > Institute of Health and Community Medicine
Depositing User: Ramji
Date Deposited: 01 Sep 2020 00:51
Last Modified: 01 Sep 2020 00:53

Actions (For repository members only: login required)

View Item View Item