Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo

Raja, Thamayanthi Nada and Hu, Ting Huey and Khamisah, Abdul Kadir and Dayang Shuaishah, Awang Mohamad and Rosli, Nawal and Wong, Lolita Lin and Hii, King Ching and Divis, Paul Cliff Simon and Singh, Balbir (2020) Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo. Emerging Infectious Diseases, 26 (8). pp. 1801-1809. ISSN 1080-6059

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To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013–December 31, 2017. Using nested PCR assays, we found 845 (80.6%) patients had either P. knowlesi monoinfection (n = 815) or co-infection with other Plasmodium species (n = 30). We noted the annual number of these zoonotic infections increased greatly in 2017 (n = 284). We identified 6 patients, 17–65 years of age, with P. cynomolgi and P. knowlesi co-infections, confirmed by phylogenetic analyses of the Plasmodium cytochrome c oxidase subunit 1 gene sequences. P. knowlesi continues to be a public health concern in the Kapit Division of Sarawak, Malaysian Borneo. In addition, another simian malaria parasite, P. cynomolgi, also is an emerging cause of malaria in humans.

Item Type: Article
Uncontrolled Keywords: Plasmodium knowlesi, malaria parasites, Malaysian Borneo, phylogenetic, P. cynomolgi, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Faculties, Institutes, Centres > Faculty of Medicine and Health Sciences
Depositing User: Simon Divis
Date Deposited: 28 Jul 2020 08:03
Last Modified: 24 May 2021 07:07

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