Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones

Liew, Yew Zion. (2008) Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones. Masters thesis, Universiti Malaysia Sarawak (UNIMAS).

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Abstract

This thesis describes the coordination chemistry of organotin(IV) with hydrazone and thiosemicarbarzone ligands. A comprehensive survey of the literature, focusing on works most pertinent and complementary to the synthesis, chemical reactivities, structures of organotin(IV) complexes and biological studies containing ONN, ONO, and ONS-donor is described extensively. New chelating hydrazone and thiosemicarbazone ligands, namely carbohydrazone bis(salicylaldehyde) [H4CBS] (1), pyruvic acid isonicotinoyl hydrazone [~PAI] (8), 2-hydroxyacetophenone thiosemicarbazone [H4APT] (14) and 3-hydroxy-2­ butanone thiosemicarbazone [H4BT] (15) have been synthesized and characterized. In general, an interesting series of new organotin(IV) complexes has been synthesized by the direct reaction of RnSnC14-n (R = Me, Bu, Ph; n = 1, 2) with these hydrazone/thiosemicarbazone ligands (1, 8, 14 & 15) in the presence of base and refluxing in 1:2:1 mole ratio (metal:base:ligand) under Schlenk Vacuum line technique.

Item Type: Thesis (Masters)
Additional Information: Thesis (M.Sc.) -- Universiti Malaysia Sarawak, 2008.
Uncontrolled Keywords: Hydrazone; thiosemicarbazone; organotin(IV); crystal structure; antibacterial; toxicity, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, Postgraduate, research, Universiti Malaysia Sarawak.
Subjects: Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Gani
Date Deposited: 12 Feb 2020 08:05
Last Modified: 12 Feb 2020 08:05
URI: http://ir.unimas.my/id/eprint/28959

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