Chemical studies and biological activities of Alpinia Ligulata

Farehah, Binti Ismail (2010) Chemical studies and biological activities of Alpinia Ligulata. [Final Year Project Report] (Unpublished)

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Abstract

A/pinia sp. is one of the largest species in Zingiberaceae family. The chemical and biological activity studies were earned out on the stems and leaves ofAlpinia /igu/a/a. Dichloromethane crude extract ofth. leaves of A. ligulata was further purified using extensive column chromatography. Compound I isolated from combined fraction 25·36 was subjected to purification process and further analyzed by using various spectroscopic techniques especially Gas Chromatography-Mass Spectrometry (GC·MS), Fourier Transform Infrared Radiation (FTIR) and Nuclear Magnetic Resonance (NMR). Compound I showed one peak at retention time of 40.774 min in the gas chromatogram. FTIR spectra showed the presence of h~roxyl (·OH), carbonyl (C~O), and phenyl group observed at 3312,1660, and 1600-1450 cm,L respectively. H-NMR and "C-NMR showed the presence of --OH group at C·3 and C-5 position, methoxy group at C-7 and C-4' and aromatic group. Compound I gave mlz value of314.05 corresponding to molecular formula ofC pH,,0, and melting point 179· 180°C, From all analysis data and comparison to published data, Compound I was characterized as 3,5­ dihydroxy-7.4 '-dimethoxyflavone or Katmpferol. 7,4 '-dimethyl ether. Termiticidal activity showed that dichloromethane, chloroform and methanol crude extracts of the stem and dichloromethane crude extract of leaves showed strong tenniticidal activity with LC,o of 1.259, 63.09, 31.62 and 5.012 flg1mL respectively. All the extract was not toxic against Artemia salina.

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc) -- Universiti Malaysia Sarawak, 2010.
Uncontrolled Keywords: chemical study, biological activity, Zingiberaceae, Alpinia ligulata, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Gani
Date Deposited: 19 Aug 2019 02:14
Last Modified: 19 Aug 2019 02:14
URI: http://ir.unimas.my/id/eprint/26511

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