Styryl Lactones from Roots and Barks Goniothalamus lanceolatus

Nurulfazlina, Edayah Rasol and Fasihuddin, Badruddin Ahmad and Mai, Chun-Wai and Nur Vicky, Bihud and Fauziah, Abdullah and Khalijah, Awang and Nor Hadiani, Ismail (2018) Styryl Lactones from Roots and Barks Goniothalamus lanceolatus. Natural Product Communications, 13 (2). pp. 1575-1578. ISSN 1934578X

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Abstract

A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8Sgoniodiol-7-monoacetate 5, 6S,7S,8S-goniodiol-8-monoacetate 6, goniofupyrone B 7, deoxygoniopypyrone B 8 and 1S,5S,7R,8S,3-endo,7-endo-(+)-8-epi-9- deoxygoniopypyrone acetate 9, along with six known styryl lactones (1, 10-15) were also isolated and characterized. 6S-goniothalamin 1 is reported for the first time from a Goniothalamus species. 1, 11 and 12 showed cytotoxic activity against human colon and lung cancer cell lines with IC50 values ranging from 2.38-7.59 µM

Item Type: Article
Uncontrolled Keywords: Goniothalamus lanceolatus, Styryl lactones, Cytotoxicity, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 16 Jul 2019 08:11
Last Modified: 02 May 2021 23:06
URI: http://ir.unimas.my/id/eprint/25910

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