XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians

Ahmad Aizat, Bin Abdul Aziz and Siti Nurfatimah, Binti Mohd Shahpudin and Mohd Aminudin, Bin Mustapha and Ravindran, Ankathil (2013) XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians. World Journal of Gastroenterology, 19 (23). pp. 3623-3628. ISSN 2219-2840

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Official URL: https://europepmc.org/abstract/med/23801864

Abstract

AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collected. DNA was extracted and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. The association between polymorphic genotype and CRC predisposition was determined using the OR and 95%CI. RESULTS: The frequency of the homozygous variant (Gln/Gln) genotype was significantly higher in cases compared with controls (16.0% vs 10.2%, P = 0.049). The Gln/Gln genotype of XPC showed a significantly higher association with the risk of CRC (OR = 1.884; 95%CI: 1.082-3.277; P = 0.025). In the case of allele frequencies, variant allele C was associated with a significantly increased risk of CRC (OR = 1.375; 95%CI: 1.050-1.802; P = 0.020). Moreover, the risk was markedly higher for those who were carriers of the Gln/Gln variant genotype and were also cigarette smokers (OR = 3.409; 95%CI: 1.061-10.949; P = 0.032). CONCLUSION: The XPC Gln/Gln genotype alone and in combination with smoking increases the risk of CRC among Malaysians.

Item Type: Article
Uncontrolled Keywords: DNA repair; Xeroderma pigmentosum group C Lys939Gln polymorphism; Cigarette smoking; Colorectal cancer; Susceptibility risk, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak.
Subjects: R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Centre for Pre-University Studies
Depositing User: Gani
Date Deposited: 04 Jul 2019 07:30
Last Modified: 04 Jul 2019 08:32
URI: http://ir.unimas.my/id/eprint/25572

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