Effect of Leptadenia Hastata Hexane leaf extracts against heamotological, biochemical and Indometachin induced ulser in rats

Umaru, Issac John and Fasihuddin, bin Badruddin Ahmad and Zaini, Bin Assim (2018) Effect of Leptadenia Hastata Hexane leaf extracts against heamotological, biochemical and Indometachin induced ulser in rats. Eurpean Journal of Pharmaceutical and Medical Research, 5 (5). pp. 35-41. ISSN 2394-3211

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EFFECT OF LEPTADENIA HASTATA HEXANE LEAF EXTRACTS AGAINST HEAMOTOLOGICAL, BIOCHEMICAL AND INDOMETHACIN INDUCED ULCER IN RATS - (abstract).pdf

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Abstract

This study was targeted at valuing a claim by traditional herbal practitioner that the leaves of Leptadenia hastata possess ulcer healing property by assessing the effect of Leptadenia hastata on ulcer induced rats. Material and method: The effects of an hexane leaf extracts of Leptadenia hastata were studied in 40 white albino rats over a period of 21days, to ascertain the claim of Leptadenia hastata has ulcerogenic properties, the rats were divided into eight groups those in group one served as control group, group two negative control (Indomethacin) ulcer induced with no treatment, while group three positive control (Omeprazole) and groups four to eight are dosed groups ranged from; 100mg/kg 200mg/kg, 300mg/kg, 400mg/kg and 500mg/kg extracts respectively, Microscopic examination was carried out and scored for the presence of lesion. The length and breadth of the lesion of the stomach was measured for ulcer index. Stomach and Blood sample were collected for Histological, hematological and biochemical analysis. The specimen of the stomach was taken for histopathological studies. Results: The study showed that the extracts of Leptadenia hastata caused increased in the weight of the rats compared to the negative control and the levels of packed cell volume, hemoglobin concentration, red blood cell, white blood cell, mean corpuscular volume and mean corpuscular hemoglobin. The changes in the biochemical parameter were all within the range of the control. Histologically, stomach degeneration was characterized by lesion and decrease number of lining cell of the epithelium. Conclusion: The study indicate that hexane leaves crude extracts of Leptadenia hastata possess ulcer healing activity.

Item Type: Article
Uncontrolled Keywords: Leptadenia hastata, ulcer, rats, histopathology, haematology, serum biochemistry, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, , research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Gani
Date Deposited: 11 Dec 2018 02:29
Last Modified: 11 Dec 2018 02:29
URI: http://ir.unimas.my/id/eprint/22701

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