Jin, S. and Kim, J.S. and Sim, S.P and Liu, A. and Pilch, D.S. and Liu, L.F. and LaVoie, E.J. (2000) Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters , 10 (8). pp. 719-723.
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Abstract
A series of 2′-heterocyclic derivatives of 5-phenyl-2,5′-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2′-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity.
| Item Type: | Article |
|---|---|
| Additional Information: | Universiti Malaysia Sarawak,(UNIMAS) |
| Uncontrolled Keywords: | UNIMAS, Universiti Malaysia Sarawak, Education, Heterocyclic bibenzimidazole, topoisomerase , |
| Subjects: | Q Science > QD Chemistry Q Science > QK Botany R Medicine > R Medicine (General) |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences Faculties, Institutes, Centres > Faculty of Medicine and Health Sciences |
| Depositing User: | Karen Kornalius |
| Date Deposited: | 05 May 2014 04:50 |
| Last Modified: | 20 Mar 2015 07:55 |
| URI: | http://ir.unimas.my/id/eprint/2241 |
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