Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls

Ferguson, L.R and Lim, I.F and Pearson, A.E and Ralph, J. and Harris, P.J. (2003) Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 542 (1-2). pp. 49-58.

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We have determined the abilities of (E)-ferulic acid, (E)-p-coumaric acid and (E,E)-5-5-dehydrodiferulic acid to protect against different types of mutation in a simple bacterial model. These antimutagenic properties were compared with those of the related compound curcumin, and also with those of an extract containing hydroxycinnamicacids obtained by the saponification of the cellwalls of wheat coleoptiles. Three known mutagens, bleomycin, hydrogen peroxide and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) were used to chemically induce reversion mutation, while the known antimutagen Trolox was used as a positive control. Both the pure hydroxycinnamicacids and the extract from the cellwalls showed antimutagenic properties. It is known that hydroxycinnamicacids ester-linked to plantcellwalls can be released in the human colon by the action of microbial esterases. Providing the current data extrapolate to mammalian cells, they suggest that antimutagenic properties of hydroxycinnamicacids released from plantcellwalls could play a role in dietary fibre protection against cancer.

Item Type: Article
Additional Information: Universiti Malaysia Sarawak,(UNIMAS)
Uncontrolled Keywords: UNIMAS, Universiti Malaysia Sarawak, IPTA, 5-5 Dehydrodiferulic acid, Antimutagen, Curcumin, Dietary fibre, Ferulic acid, Hydroxycinnamic acid, p-Coumaric acid, Salmonella
Subjects: R Medicine > R Medicine (General)
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Karen Kornalius
Date Deposited: 05 May 2014 01:32
Last Modified: 19 Jan 2022 02:07

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