Review on the Synthesis of Pyrazine and Its Derivatives

Kok, Tong Ong and Liu, Zhi-Oiang and Meng, Guan Tay (2017) Review on the Synthesis of Pyrazine and Its Derivatives. Borneo Journal of Resource Science and Technology, 7 (2). pp. 60-75. ISSN 2229-9769

[img] PDF
Review on.pdf

Download (155kB)
Official URL:


Pyrazine is a kind of natural product which can be found in plants, animals, insects, marine organisms and microorganisms. The main function of pyrazine in living organisms is used as flavor of the raw foods. Pyrazine and its derivatives were also produced in industries mainly for fragrance, flavor and pharmaceutical applications. This review describes the historical development of pyrazine including the discovery and synthesis, to the recent synthetic approach of pyrazinium. In general, six synthetic approaches namely condensation reaction, ring closure, metal catalysis, green reaction, Maillard reaction and acid catalyst on N-substitution have been reviewed in this paper. The first five approaches are mainly aimed for the substitution at 2, 3, 5 and 6 positions in pyrazine ring, whereas the last approach is specifically for 1 and 4 positions in pyrazine.

Item Type: Article
Uncontrolled Keywords: Diazine, pyrazine, and Maillard reaction, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Faculties, Institutes, Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 03 Oct 2018 01:15
Last Modified: 21 Jun 2022 03:31

Actions (For repository members only: login required)

View Item View Item