Phytochemical studies and pharmacophore analysis of sonneratia caseolaris fruits

Liyana Zafirah, Othman. (2016) Phytochemical studies and pharmacophore analysis of sonneratia caseolaris fruits. [Final Year Project Report] (Unpublished)

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Abstract

The aim for this study was to isolate the bioactive molecules, determine the biological activities and find the potential lead in Sonneratia caseolaris as antimicrobial drugs. Phytochemical examination on the methanol extract of the fruits gave about 37.37 g of crude and 4.82 % percentage yield which led to the isolation and characterization of compound I. This structure compound were elucidated and characterized by spectroscopic analysis by using IH and l3C Nuclear Magnetic Resonance (NMR) Spectroscopy, and Fourier Transform Infrared Spectroscopy (FTIR). In ligand-based pharmacophore modelling, the interaction of compound I with generated pharmacophore model shows the presence of hydrophobic (HY) and hydrogen bond acceptor (HBA) pharmacophore features with fit value of 35.4800. Biological evaluations were carried out on the methanol and hexane crude extracts. The results stated that the methanol crude extracts has higher LCso value that was 2344.0 ppm. This higher value indicated that compound has no toxicity towards Artemia salina. In disc diffusion for antimicrobial test, it was found that Sonneratia caseolaris crude showed weak inhibition zone (7.33 mm and 7.00 mm) towards Escherichia coli and mild inhibition towards Staphylococcus at/rells for both methanol and hexane crude

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2016.
Uncontrolled Keywords: Antimicrobial, toxicity, biological evaluations, pharmacophore modelling, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, , research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Gani
Date Deposited: 25 Jul 2018 08:26
Last Modified: 14 Jul 2021 13:57
URI: http://ir.unimas.my/id/eprint/20898

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