Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus

Adibah, binti Ahamad Bahtiar. (2008) Synergistic effect of ribavirin in combination treatment with lemon grass (cymbopogon nardus (L.) rendle) fractions SWA13 and SWB6 towards measles virus. [Final Year Project Report] (Unpublished)

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Abstract

An in vitro study was carried out to investigate the antiviral activity in SWA13 and SWB6 fractions of Cymbopogon nardus (L.) Rendle and the synergistic effects from combination of the fractions with ribavirin towards measles virus. The antiviral activity was conducted by treating Vero/SLAM cells with two concentrations for C. nardus (0.1 LC50 and 0.5 LC50) and ribavirin (0.01CC50 and 0.005CC50). Two protocols were used in this study. Protocol I [(S+V)+A] was done by inoculating the virus (V) to the cells (S) before being treated with antiviral compounds (A). Protocol II [(S+A)+V], involved inoculation of the cells with virus after treatment with antiviral compounds. The antiviral activity was based on comparison of percentage of cells viability in viral inoculated cells with the control. Data was analyzed using one-way ANOVA and significant data was analyzed with Tukey’s Test. Results of monotherapy showed moderate antiviral activity of SWA13 in Protocol I but low activity in Protocol II. SWB6 exerted low antiviral activity in both protocols. Synergistic effect was observed from combination treatment of 0.005 CC50 RBV + 0.1 LC50 SWB6 in Protocol II with 80.23% cells viability. Further evaluation should be done to identify the active compounds and mechanisms of action of C. nardus extracts

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2008.
Uncontrolled Keywords: Cymbopogon nardus, ribavirin, synergistic effect, combination treatment, monotherapy, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Gani
Date Deposited: 18 Jul 2018 02:00
Last Modified: 18 Jul 2018 02:00
URI: http://ir.unimas.my/id/eprint/20800

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