Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq.

Rasol, Nurulfazlina Edayah and Ahmad, Fasihuddin Badruddin and Lim, Xiangyin and Chung, Felicia Fei Lei and Leong, Cheeonn and Mai, Chun Wai and Bihud, Nur Vicky and Zaki, Hamizah Mohd and Ismail, Nor Hadiani (2018) Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq. Phytochemistry Letters, 24. pp. 51-55. ISSN 18743900

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Abstract

Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatus (Annonaceae). The structures were elucidated by spectroscopic techniques and the absolute configuration of 1 was established by single-crystal X-ray diffraction. Alkaloid 1 showed cytotoxic activity on human colon and lung cancer cell lines with IC50 values ranging from 5.32 to 9.91 μM. © 2018 Phytochemical Society of Europe

Item Type: E-Article
Uncontrolled Keywords: Annonaceae, Cytotoxic activity, Goniothalamus lanceolatus, Lactam alkaloid, Naphthoquinone alkaloids,unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: S Agriculture > S Agriculture (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Ibrahim
Date Deposited: 19 Mar 2018 06:42
Last Modified: 12 Jul 2019 02:05
URI: http://ir.unimas.my/id/eprint/19852

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