Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida]

Nornadia, Jasin and Meng, Guan Tay and Hashimatul Fatma, Hashim (2017) Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida]. Malaysian Journal of Analytical Sciences, 21 (5). pp. 1195-1202. ISSN 13942506

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Official URL: http://www.ukm.my/mjas/mjas2018/

Abstract

A series of hydrazone Schiff base (compounds S, S8, S10 and S12) were synthesized by condensation reaction of salicylhydrazide with 3-hydroxybenzaldehyde, 3-(octyloxy)benzaldehyde, 3-(decyloxy)benzaldehyde and 3-(dodecyloxy) benzaldehyde, respectively. Herein, the addition of alkane numbers are reported using suscessful Williamson etherification method by reacting 3-hydroxybenzaldehyde with bromooctane, bromodecane and bromododecane, respectively. All compounds were characterised using Fourier Transform Infrared and 1H Nuclear Mangnetic Resonance spectroscopic. The compounds were assayed to antibacterial activity against Gram-positive and Gram-negative bacteria using Bacillus cereus and Escherichia coli by disc diffusion method. Interestingly, among the compounds tested S8 showed a strong inhibition against Escherichia coli and none of the compounds tested show significant result against Bacillus cereus.

Item Type: Article
Uncontrolled Keywords: 3-hydroxybenzaldehyde, Williamson etherification, hydrazone Schiff base, antibacterial activity, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Ibrahim
Date Deposited: 30 Jan 2018 02:03
Last Modified: 30 Jan 2018 02:03
URI: http://ir.unimas.my/id/eprint/18936

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