Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities

Ainaa Nadiah, Abd Halim and Zainab, Ngaini (2017) Synthesis and characterisation of halogenated bis(acylthiourea) derivatives and its antibacterial activities. Phosphorus, Sulfur, and Silicon and the Related Elements, 192 (9). ISSN 10426507

Full text not available from this repository. (Request a copy)
Official URL: https://www.researchgate.net/publication/316030203

Abstract

A total of 12 bis(acylthiourea) derivatives with different pharmacophores have been synthesized via nucleophilic substitution reaction of benzene-1,4-dicarbonyl isothiocyanate intermediate with aromatic amine bearing halogens at the ortho, meta and para positions. The structures of the synthesised compounds were confirmed by CHN elemental analysis, FT-IR, ¹H NMR and ¹³C NMR spectroscopies. Antibacterial studies of the compounds via the Kirby Bauer disc diffusion method against Escherichia coli (E.coli) ATCC 25922 and Staphylococcus aureus (S. aureus) S48/81 demonstrated that bis(acylthiourea) N¹,N⁴-bis[(2-chlorophenyl)carbamothioyl]terephthalamide (4) and N¹,N⁴-bis[(2-bromophenyl)carbamothioyl]terephthalamide (7) bearing Cl and Br at the ortho position exhibited excellent activities against both bacteria strains compared to ampicillin standard.

Item Type: Article
Uncontrolled Keywords: Bis(acylthiourea), antibacterial activity, aromatic amine, halogen, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: Q Science > Q Science (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 09 Nov 2017 07:36
Last Modified: 09 Nov 2017 07:36
URI: http://ir.unimas.my/id/eprint/18505

Actions (For repository members only: login required)

View Item View Item