Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death

Octavio, Carvajal-Zarrabal and Patricia M., Hayward-Jones and Cirilo Nolasco, Nolasco-Hipólito and Dulce, Barradas-Dermitz and Ana Laura, Calderón-Garcidueñas and Noe, Lopez-Amador (2017) Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death. Journal of Forensic Sciences, 62 (5). pp. 1332-1335. ISSN 0022-1198

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In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.

Item Type: Article
Uncontrolled Keywords: cardiac injury biomarkers, forensic pathology, forensic science, postmortem, sudden cardiac death, troponin I, troponin T, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, reseach, Universiti Malaysia Sarawak
Subjects: T Technology > TP Chemical technology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Engineering
Faculties, Institutes, Centres > Faculty of Engineering
Depositing User: Karen Kornalius
Date Deposited: 02 Oct 2017 07:05
Last Modified: 02 Oct 2017 07:05

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