Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles

Pang, S.C. and Tay, S.H. and Chin, S.F. (2014) Facile Synthesis of Curcumin-Loaded Starch-Maleate Nanoparticles. Journal of Nanomaterials.

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Official URL: http://dx.doi.org/10.1155/2014/824025

Abstract

We have demonstrated the loading of curcumin onto starch maleate (SM) under mild conditions by mixing dissolved curcumin and SM nanoparticles separately in absolute ethanol and ethanol/aqueous (40 : 60 v/v), respectively. Curcumin-loaded starch-maleate (CurSM) nanoparticles were subsequently precipitated from a homogeneous mixture of these solutions in absolute ethanol based on the solvent exchange method. TEM analysis indicated that the diameters of CurSM nanoparticles were ranged between 30 nm and 110 nm with a mean diameter of 50 nm. The curcumin loading capacity of SM as a function of loading duration was investigated using the UV-visible spectrophotometer. The loading of curcumin onto SM increased rapidly initially with loading duration, and the curcumin loading capacity of 15 mg/g was reached within 12 hours. CurSM nanoparticles exhibited substantially higher water solubility of 6.0 × 10−2 mg/mL which is about 300 times higher than that of pure curcumin. With enhanced water solubility and bioaccessibility of curcumin, the potential utility of CurSM nanoparticles in various biomedical applications is therefore envisaged.

Item Type: Article
Additional Information: Universiti Malaysia Sarawak, UNIMAS
Uncontrolled Keywords: starch maleate, Curcumin-loaded starch-maleate, SM, CurSM, nanoparticles, FSTS, Universiti Malaysia Sarawak, UNIMAS, university, universiti, Malaysia, Sarawak, Kuching, Samarahan, IPTA, education,undergraduate,postgraduate, research
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 28 Mar 2014 08:06
Last Modified: 14 Sep 2015 01:39
URI: http://ir.unimas.my/id/eprint/1572

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