Synthesis and Antibacterial Study of Aspirin-Chalcone Derivatives

Zainab, Ngaini and Ho, Doris Ai Hui and Hasnain, Hussain and Wan Sharifatun Handayani, binti Wan Zullkiplee and Meng, Guan Tay and Norhasnan, Sahari and Norsyafikah Asyilla, Nordin (2013) Synthesis and Antibacterial Study of Aspirin-Chalcone Derivatives. Borneo Journal of Resource Science and Technology, 3 (1). pp. 52-57. ISSN 2229-9769

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The chemistry of aspirin and chalcone derivatives has been extensively studied and developed as one of the pharmaceutically important molecules. In this study, new aspirin-chalcone derivatives have been successfully synthesized and characterized via FTIR, 1H and 13C NMR spectroscopy. The antibacterial activities of synthesized compounds were investigated towards Escherichia coli ATCC 8739 via turbidimetric kinetic method. The newly synthesized aspirin-chalcone derivatives, however showed poor antibacterial activity against E. coli ATCC 8739 at the concentration of 50, 80 and 100 ppm. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed.

Item Type: Article
Uncontrolled Keywords: Aspirin, chalcone, antimicrobial, E. coli, research, Universiti Malaysia Sarawak, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education
Subjects: Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 15 Mar 2017 10:33
Last Modified: 30 Apr 2021 05:00

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