Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities

Wan Sharifatun Handayani, Wan Zullkiplee and Ainaa Nadiah, Abd Halim and Zainab, Ngaini and Maya Asyikin, Mohd Ariff and Hasnain, Hussain (2016) Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities. Phosphorus Sulfur and Silicon and the Related Elements, 189 (6). ISSN 1042-6507

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Abstract

A series of symmetrical 1,3-bis thiourea 1a–e and 1,4-bis thiourea derivatives 2a–e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed.

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