Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones

Syed Salman, Shafqat and Amir Azam, Khan and Misbahulain, Khan and Kuan, Nicholas Hoo Tien and Mohd Syahmi, Jamaludin and Pang, Suh Cem (2016) Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones. MATEC Web of Conferences, 87. ISSN 2261236X

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A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Reactions give excellent yields under reflux conditions. The chemical structures of these compounds were identified by Fourier Transform-Infra Red Spectroscopy (FT-IR), Gas Chromatography-Mass Spectroscopy (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1H NMR). Physical parameters such as m.p., mixed m.p. as well as TLC also helped to characterize the expected products. The progress of the reaction time and purity was checked by TLC and the products were purified by recrystallization using ethyl acetate as a solvent. The synthesized molecule has numerous biological applications as it is anti-microbial, anti-inflammatory and anti-hypertensive in character

Item Type: Article
Uncontrolled Keywords: 4-Aryldihydropyrimidinone; Amino Acids; Green Approach, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: T Technology > TJ Mechanical engineering and machinery
Divisions: Academic Faculties, Institutes and Centres > Faculty of Engineering
Faculties, Institutes, Centres > Faculty of Engineering
Depositing User: Ibrahim
Date Deposited: 03 Feb 2017 08:12
Last Modified: 09 Jun 2021 14:59
URI: http://ir.unimas.my/id/eprint/15184

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