Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity

Wan Zullkiplee, Wan Sharifatun Handayani (2011) Synthesis And Characterization Of Bis Thiourea Derivatives Another Antibacterial Activity. [Final Year Project Report] (Unpublished)


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Thiourea and its derivatives are well known as potent antibacterial and antifungal agents. This research focused on the synthesis of bis thiourea derivatives with two thiourea groups resulting from the reactions of 3-acetylbenzoyl isothiocyanate intermediate with appropriate amine group from certain amino acids and aniline. Five bis thiourea derivatives have been synthesized. The successfully synthesized compounds were characterized using FTIR, IH NMR and DC NMR and found to be in highly purity compound. Antibacterial assay was carried out using turbidimetric method against the growth of Escherichia Coliform sp. (E. coli). However, the result indicated that the newly synthesized bis thiourea derivatives showed poor antibacterial activity against E. coli. The effect of the structure of the investigated compounds on the antibacterial activity is discussed.

Item Type: Final Year Project Report
Uncontrolled Keywords: Bis thiourea, Antibacterial activity, Amino acid, Universiti Malaysia Sarawak, UNIMAS, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate
Subjects: Q Science > QR Microbiology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 25 Mar 2014 06:27
Last Modified: 18 Aug 2015 01:49

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