Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit

Ui-Hang, Edmund Sim and Chin-Ming, Er (2015) Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit. International Journal of Bioscience, Biochemistry and Bioinformatics, 5 (2). ISSN 2010-3638

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Abstract

Extra-ribosomal functions of ribosomal proteins have been widely accepted albeit an incomplete understanding of these roles. Standard experimental studies have limited usefulness in defining the complete biological significance of ribosomal proteins. An alternative strategy is via in silico analysis. Here, we sought a sequence-to-structure-to-function approach to computationally predict the extra-ribosomal functions of a subset of ribosomal proteins of the small ribosome subunit, namely RPS12, RPS19, RPS20 and RPS24. Three-dimensional structure constructed from amino acid sequence was precisely matched with structural neighbours to extrapolate possible functions. Our analysis reveals new logical roles for these ribosomal proteins, of which represent important information for planning experimental and further in silico studies to elucidate their physiological roles.

Item Type: E-Article
Uncontrolled Keywords: Extra-ribosomal functions, RPS12, RPS19, RPS20, RPS24, structural neighbours, 3D modelling, research, Universiti Malaysia Sarawak, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education
Subjects: Q Science > Q Science (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 15 Aug 2016 23:42
Last Modified: 15 Aug 2016 23:42
URI: http://ir.unimas.my/id/eprint/13008

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