Clinical correlates of in vitro Plasmodium falciparum cytoadherence

Ho, M. and Balbir, Singh and Looareesuwan, S. and Davis, T.M.E and Bunnang, D. and White, Nicholas J. (1991) Clinical correlates of in vitro Plasmodium falciparum cytoadherence. Infection and Immunity, 59 (3). pp. 873-878. ISSN 0019-9567

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To determine whether isolates of Plasmodiumfalciparum have intrinsically different cytoadherent properties and whether these differences contribute to the clinical severity of human falciparum malaria, we studied the cytoadherence to C32 melanoma cells in vitro of 59 parasite isolates from patients with naturally acquired infections in Thailand. Parasitized erythrocytes adhere to these melanoma cells principally via the glycoprotein CD36, which is also expressed on most vascular endothelium. In vitro cytoadherence was significantly greater for isolates from patients with biochemical evidence of severe malaria. The cytoadherent properties of P. falciparum parasites may thus be a virulence factor in human falciparum malaria. However, there was no correlation between the degree of in vitro cytoadherence and cerebral symptoms, which suggests that other receptors and/or host factors may be important in the adherence of malaria parasites to cerebral vascular endothelium. The cytokines tumor necrosis factor, interleukin-1, and gamma interferon, which have been implicated in the pathogenesis of cerebral malaria and are known to promote intercellular adhesion in other systems, did not enhance the cytoadherence of P. falciparum isolates to C32 melanoma cells.

Item Type: Article
Uncontrolled Keywords: Plasmodium falciparum, cytoadherent properties, P. falciparum parasites, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Karen Kornalius
Date Deposited: 05 Apr 2017 08:02
Last Modified: 05 Apr 2017 08:02

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