Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever

Cardosa, Mary Jane and Mong, How Ooi and Phaik, Hooi Tio and David, Perera and Holmes, Edward C. and Khatijar, Bibi and Zahara, Abd Manap (2009) Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever. PLOS Neglected Tropical Diseases, 3 (4). ISSN 1935-2727

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Official URL: http://journals.plos.org/plosntds/article?id=10.13...

Abstract

Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (DHF) with thrombocytopenia (12,000/ul) and a raise hematocrit (29.5% above baseline) in January 2008 in Malaysia. Dengue virus serotype 2 was isolated from his blood on day 4 of fever. A phylogenetic analysis of the complete genome sequence revealed that this virus was a member of a sylvatic lineage of DENV-2 and most closely related to a virus isolated from a sentinel monkey in Malaysia in 1970. This is the first identification of a sylvatic DENV circulating in Asia since 1975.

Item Type: Article
Uncontrolled Keywords: Dengue viruses, dengue hemorrhagic fever (DHF), unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Institute of Health and Community Medicine
Depositing User: Karen Kornalius
Date Deposited: 03 Apr 2017 06:48
Last Modified: 03 Apr 2017 06:48
URI: http://ir.unimas.my/id/eprint/15786

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