Small Cell Transformation and T790M Mutation as Coresistance Mechanisms for First-line Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) Therapy Failure

Chee, Shee Chai (2017) Small Cell Transformation and T790M Mutation as Coresistance Mechanisms for First-line Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) Therapy Failure. Journal of Thoracic Oncology, 12 (10). pp. 171-173. ISSN 1556-0864

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Abstract

Discovery of the activating EGFR mutation gene has revolutionized the treatment of patients with NSCLC. Nevertheless, resistance to first-line EGFR tyrosine kinase inhibitors (TKIs) develops in most patients with EGFR-mutant NSCLC after a period of 9 to 13 months. Here, we reported a case of first-line EGFR TKI failure attributed to SCLC transformation and T790M mutation

Item Type: Article
Uncontrolled Keywords: Medicine, tumor, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Faculties, Institutes, Centres > Faculty of Medicine and Health Sciences
Depositing User: Karen Kornalius
Date Deposited: 03 Jan 2018 07:10
Last Modified: 08 Jun 2022 07:56
URI: http://ir.unimas.my/id/eprint/19173

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