Characterization of marine penicillium isolates and their antibiotics

Mohd.Noorzaifiqrudin, bin Khairol (2012) Characterization of marine penicillium isolates and their antibiotics. [Project Report] (Unpublished)

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brought to human and animal health. Penicillium sp. have been known as their potential of producing antimicrobial compounds. Recently, this species were discovered to produce more than one type of antimicrobial compounds. This discovery has been promising to encounter the ongoing emergence of antibiotic resistant microorganisms. In this study, a total of five pure fungal isolates were cultivated from marine environment. Out of five, two of them were putatively identified as P. oxalicum and Ampelomyces sp. From the preliminary test of fungi isolates, a'imost all the isolates were shown to have strong antibacterial activity against test bacteria, which were S. aureus, a Gram-positive bacteria as well as S. typhi, E. coli and E. aerogenes, Gramnegative bacteria. Contrary to this, only dichloromethane extracts of isolates SVM3 and SVP4 (PDA) were active against S. aureus observed in disc diffusion assay. The results were also inconsistent with the bioautography assay of the extracts, which showed only dichloromethane extracts of SVP4 (CDA) and SVM3 were active against S. aureus and E. aerogenes, respectively. The active compound in bioautography assay might be penicillin, as compared to penicillin-streptomycin as reference.

Item Type: Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2012.
Uncontrolled Keywords: Penicillium, Penicillium oxalicum, Ampelomyces, bioautography assay, disc diffusion assay, research, Universiti Malaysia Sarawak, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate
Subjects: Q Science > QR Microbiology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 01 Jul 2015 01:58
Last Modified: 01 Jul 2015 01:58

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