Synthesis, characterization and antibacterial activity of bis thiourea derivatives

Ainaa Nadiah, Binti Abd Halim (2013) Synthesis, characterization and antibacterial activity of bis thiourea derivatives. [Project Report] (Unpublished)

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Abstract

A series of bis(thiourea) derivatives were successfully synthesized by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates, with amino acid and aromatic amine to afford thiourea 20-24 with overall yields of 11–58%. The structures of the synthesized compounds were characterized by infra red spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR), and 1H NMR spectroscopy. The antibacterial activities of thiourea 20-24 were investigated on gram-negative bacteria, Escherichia coli using turbidimetric kinetic method. Minimum inhibition concentration (MIC) values of the compounds toward the bacteria were determined. The result obtained in this study indicated that only N1,N4- bis(phenylcarbamothioyl)terephthalamide 22 showed antibacterial activity against E. coli compared with other synthesized compounds.

Item Type: Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2013.
Uncontrolled Keywords: Urea derivatives,Thiourea,Unimas, university,universiti, Borneo, Malaysia, Sarawak,Kuching,Samarahan,ipta,education, undergraduate, research ,Universiti Malaysia Sarawak
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 20 May 2015 03:39
Last Modified: 22 Mar 2016 03:13
URI: http://ir.unimas.my/id/eprint/7608

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