Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands

Nur Hafizah, bt Ramli (2012) Synthesis, spectral studies and cytotoxicity of organotin(IV) complexes with hydrazone ligands. [Project Report] (Unpublished)

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Abstract

Eight new organotin(IV) complexes of 2-hydroxy-3-methoxybenzaldehyde isonicotinylhydrazone [L1 (1)] with general formula [RnSnCl3-n (L1)] [ R = Me, n = 2 (3); R = Bu, n = 2 (4); R = Ph, n = 2 (5); R = Me, n = 1 (6); R = Bu, n = 1 (7); R= Ph, n= 1 (8)] were synthesized by direct reaction of the ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2 atmosphere. Another four organotin(IV) complexes of paminoacetophenone isonicotinylhydrazone [L2 (2)] with general formula [RnSnCl3-n] [ R = Me, n = 2 (9); R = Bu, n = 2 (10); R = Me, n = 1 (11); R = Ph, n = 1 (12)] were also synthesized by direct reaction of the ligand (2), base and organotin(IV) chloride(s). The ligands (1-2) and their organotin(IV) complexes (3-12) have been characterized by elemental analyses, UV-Visible, FT-IR and 1H NMR spectral studies. Spectroscopic data suggested that ligand (1) acted as a dinegative tridentate and ligand (2) acted as uninegative bidentate chelating agent. The toxicity of the hydrazone ligands (1-2) and their selected organotin(IV) complexes were evaluated against Artemia salina. The results shown that the selected organotin(IV) complexes have better cytotoxicity than the free ligands (1-2). Furthermore, it has been shown that diphenyltin(IV) complex exhibit significantly better activity than the other organotin derivatives.

Item Type: Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2012.
Uncontrolled Keywords: Hydrazones, Hydrazone ligands, organotin(IV) complexes, toxicity, Universiti Malaysia Sarawak, UNIMAS, universiti, university, Borneo, Malaysia, Sarawak, Kuching, Samarahan, IPTA, education, undergraduate, research
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 21 Jan 2015 07:14
Last Modified: 13 May 2015 04:50
URI: http://ir.unimas.my/id/eprint/6272

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