MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay_a case control study

Hayati, AR and Zainal, AI and Tan, G.C and Ong, L.C and Khoo, T.B (2008) MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay_a case control study. Med J Malaysia, 63 (5). pp. 379-383.

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Abstract

Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. This association has not been found in some ethnic groups. In this study, we attempted to assess the association between NTDs and MTHFR C677T in Malaysian Malay population. Results show that MTHFR 677TT genotype was absent in both patient and control groups.

Item Type: Article
Additional Information: Universiti Malaysia Sarawak,(UNIMAS)
Uncontrolled Keywords: UNIMAS, Universiti Malaysia Sarawak, Education, MTHFR C677T polymorphism, neural tube, Malay, congenital malformations,
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RB Pathology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Karen Kornalius
Date Deposited: 05 May 2014 07:49
Last Modified: 20 Mar 2015 01:29
URI: http://ir.unimas.my/id/eprint/2260

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