Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Jin, S. and Kim, J.S. and Sim, S.P and Liu, A. and Pilch, D.S. and Liu, L.F. and LaVoie, E.J. (2000) Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters , 10 (8). pp. 719-723.

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Abstract

A series of 2′-heterocyclic derivatives of 5-phenyl-2,5′-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2′-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity.

Item Type: Article
Additional Information: Universiti Malaysia Sarawak,(UNIMAS)
Uncontrolled Keywords: UNIMAS, Universiti Malaysia Sarawak, Education, Heterocyclic bibenzimidazole, topoisomerase ,
Subjects: Q Science > QD Chemistry
Q Science > QK Botany
R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Karen Kornalius
Date Deposited: 05 May 2014 04:50
Last Modified: 20 Mar 2015 07:55
URI: http://ir.unimas.my/id/eprint/2241

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