An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia

Mohammad Zulkarnaen, Ahmad Narihan and Hayati, Abdul Rahman (2007) An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia. International Journal of Gynecological Pathology, 26 (1). pp. 83-88.

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Abstract

Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillomavirus infection within the epithelial layer, the presence of dentritic cells or Langerhans cells in epithelial layer of the ectocervix is paramount in producing immune response. The mature dentritic cells express CD83 and high CD40/80/86, whereas the immature cells express CD1a and low CD40/80/86. By identifying CD1a and CD83, theoretically, both immature and mature dentritic cell populations can be studied. In view of the facts, we investigated the infiltrating cell density of mature and immature dentritic cells in cervical neoplasia.

Item Type: Article
Additional Information: Universiti Malaysia Sarawak,(UNIMAS)
Uncontrolled Keywords: UNIMAS, Universiti Malaysia Sarawak, Immunohistochemical Study, CD1a, CD83-Positive, Cervical Neoplasia,
Subjects: R Medicine > RB Pathology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Karen Kornalius
Date Deposited: 05 May 2014 00:57
Last Modified: 20 Mar 2015 06:03
URI: http://ir.unimas.my/id/eprint/2212

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