Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines

Hui, Suzie Chin Kuan and Wei, Sun and Lu, Wang and Chungu, Xia and Meng, Guan Tay and Chao, Liu (2017) Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines. Advanced Synthesis & Catalysis, 359 (16). ISSN 1615-4169

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Abstract

A novel double carbonylation process has been demonstrated with easily available HCOCOH (glyoxal) as the double carbonylation reagent. Simple CuCl2·2H2O (copper(II) chloride dihydrate) was used as the oxidant for this transformation. Under optimized reaction conditions, various primary and secondary anilines were double-carbonylated to afford their corresponding isatins (26 examples, up to 80% yields).

Item Type: Article
Uncontrolled Keywords: Double Carbonlyation, Isatin Synthesis, Glyoxal, Anilines, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 21 Aug 2017 04:58
Last Modified: 21 Aug 2017 04:58
URI: http://ir.unimas.my/id/eprint/17313

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