Preliminary findings of down-regulated genes in nasopharyngeal carcinoma

Sim, Edmund U. H. and Kie-Leong, Alan Toh and Thung-Sing, Tiong (2008) Preliminary findings of down-regulated genes in nasopharyngeal carcinoma. Asia Pacific Journal of Molecular Biology and Biotechnology, 16 (3). pp. 79-84. ISSN 0128-7451

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Abstract

The cause and mechanism of nasopharyngeal carcinoma (NPC) progression are multifactorial and multigenic in nature. Despite the increasing number of genes found to be linked with NPC, the comprehensive list of associated genetic factors remains incomplete and the precise molecular pathways to this cancer are largely undefined. Here we show early evidence of possible association between several genes and the tumourigenesis of NPC. By employing the GeneFishingTM DEG Technique that allows the comparative analysis of expression profiles between normal and tumour nasopharyngeal biopsy tissues, we have identified 10 differentially expressed genes. These genes were down-regulated in tumours relative to normal control and have never been brought into the context of NPC tumourigenicity. Our findings represent preliminary yet novel clues of several associative genetic factors to neoplastic malignancy of the nasopharynx.

Item Type: Article
Uncontrolled Keywords: Differentially expressed genes, Nasopharyngeal carcinoma, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 18 Jul 2017 07:38
Last Modified: 18 Jul 2017 07:38
URI: http://ir.unimas.my/id/eprint/16916

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