Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections

Cox-Singh, J. and Balbir, Singh and Daneshvar, C. and Planche, Timothy and Parker-Williams, John and Sanjeev, Krishna (2011) Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections. PLoS ONE, 6 (6). ISSN 1932-6203

[img]
Preview
PDF
Anti-Inflammatory Cytokines Predominate in Acute (abstract).pdf

Download (50kB) | Preview

Abstract

Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection. Therefore pre-treatment cytokine and chemokine profiles were determined for 94 P. knowlesi, and for comparison, 20, P. vivax and 22 P. falciparum, patients recruited in Malaysian Borneo. Nine, five and one patient with P. knowlesi, P. falciparum and P. vivax respectively had complicated malaria as defined by World Health Organisation. Patients with uncomplicated P. knowlesi had lower levels of the pro-inflammatory cytokines IL-8 and TNFa than those with complicated disease (both p,0.05, Dunn’s post test, DPT). The anti-inflammatory cytokines IL-1ra and IL-10 were detected in all patients in the study. IL-1ra, the most abundant cytokine measured, correlated with parasitaemia in P. knowlesi (rs = 0.47, p = ,0.0001), P. vivax (rs = 0.61, p = 0.0042) and P. falciparum (rs = 0.57,p = 0.0054) malaria. IL-10 correlated with parasitaemia in both P. knowlesi (rs = 0.54, p = ,0.0001) and P. vivax (rs = 0.78, p = ,0.0001) infections. There were between group differences in soluble markers of macrophage activation (MIP-1b and MCP-1). P. knowlesi patients had significantly lower levels of MIP-1b than P. falciparum (DPT, p = ,0.01). Uncomplicated P. knowlesi patients had significantly lower levels of MCP-1 than uncomplicated P. falciparum patients (DPT, p = ,0.001). There was no significant difference between complicated and uncomplicated P. knowlesi infections. MCP-1, MIP-1b, IL-8 and TNFa increased in complicated P. knowlesi but decreased in complicated P. falciparum infections. Descriptions of human knowlesi malaria provide a comparative means to discover mediators of pathophysiology in severe P. knowlesi as well as P. falciparum malaria. Crucially, P. knowlesi may be the disease and experimental primate model for severe malaria.

Item Type: Article
Uncontrolled Keywords: Plasmodium knowlesi, knowlesi malaria, pre-treatment cytokine, chemokine, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: Q Science > Q Science (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Karen Kornalius
Date Deposited: 04 Apr 2017 04:42
Last Modified: 04 Apr 2017 04:42
URI: http://ir.unimas.my/id/eprint/15806

Actions (For repository members only: login required)

View Item View Item