Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents

Norsyafikah Asyilla, Binti Nordin and Tchan, Wei Chai and Bee, Ling Tan and Ching, Liang Choi and Ainaa Nadiah, Abd Halim and Hasnain, Hussain and Zainab, Ngaini (2017) Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents. Journal of Chemistry, 2017. ISSN 2090-9071

[img]
Preview
PDF
Novel Synthetic Monothiourea Aspirin Derivatives (abstract).pdf

Download (86kB) | Preview

Abstract

A new series of aspirin bearing alkylated amines moieties 1–12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16–56%. The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1H and 13C NMR spectroscopy. All compounds were evaluated for antibacterial activities against E. coli and S. aureus via turbidimetric kinetic and Kirby Bauer disc diffusion method. Compound 5 bearing meta -CH3 substituent showed the highest relative inhibition zone diameter against tested bacteria compared to ortho and para substituent. Furthermore, aspirin derivatives bearing shorter chains exhibited better bacterial inhibition than longer alkyl chains.

Item Type: Article
Uncontrolled Keywords: aspirin bearing alkylated amines, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, Chemistry, research, Universiti Malaysia Sarawak
Subjects: Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 20 Feb 2017 06:48
Last Modified: 15 Mar 2017 09:49
URI: http://ir.unimas.my/id/eprint/15374

Actions (For repository members only: login required)

View Item View Item