Aleukemic bcr-abl positive granulocytic sarcoma

Kuan, Jew-Win and Pathmanathan, Rajadurai and Chang, Kian Meng and Tan, Sen Mui (2009) Aleukemic bcr-abl positive granulocytic sarcoma. Leukemia Research, 33 (11). pp. 1574-1577. ISSN 0145-2126

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Abstract

Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcrabl, PML-RARAandCBFB/MYH11 in bone marrowor peripheral blood,many cases of the so called ‘primary’ GS are questionable. We report a case of primary GS where the tumor mass bcr-abl translocation was demonstrated by fluorescent in situ hybridization in which there was no evidence of chronic myeloid leukemia (CML). This is an important finding as it highlights the possibility that CML may present as a sole extramedullary form, and illustrates potential treatment by tyrosine kinase inhibitor.

Item Type: Article
Uncontrolled Keywords: Granulocytic sarcoma, Bcr-abl, CML, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Win
Date Deposited: 10 Jun 2016 07:44
Last Modified: 10 Jun 2016 07:44
URI: http://ir.unimas.my/id/eprint/12279

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