Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity

Choi, Ching Liang (2015) Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity. [Project Report] (Unpublished)

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Abstract

Thiourea and its derivatives have been actively studied in recent years mostly in their biological activities. This study focused on the synthesis and characterization of aspirinthiourea derivatives. The syntheses have been done via the reaction of acetylsalicyloyl chloride with series of amines. The long chains of amine formed by using 4-hydroxyl acetanilide and a series of bromoalkane have been synthesized. The synthesis aspirinthiourea derivatives were characterized by Fourier transform infrared spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR) and 1H NMR spectroscopy. The antibacterial properties of the synthesized compound were determined by disc diffusion method against Escherichia Coli (E.coli). However, the newly synthesized aspirin-thiourea derivatives show intermediate antibacterial activity against E.coli. The effect of the structure of the compounds on antibacterial activity is discussed.

Item Type: Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2015.
Uncontrolled Keywords: unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, research, Universiti Malaysia Sarawak, Thiourea, acetylsalicyloyl chloride, 4-hydroxyl acetanilide, antibacterial properties
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 21 Mar 2016 07:42
Last Modified: 21 Mar 2016 07:42
URI: http://ir.unimas.my/id/eprint/11049

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