Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity

Choi, Ching Liang (2015) Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity. [Final Year Project Report] (Unpublished)

[img] PDF
Choi Ching Liang 24pgs.pdf
Download (421kB)
[img] PDF (Please get the password by email to repository@unimas.my , or call ext: 082-583914/3933/ 3942)
Choi Ching Liang ft.pdf
Restricted to Registered users only
Download (2MB)

Abstract

Thiourea and its derivatives have been actively studied in recent years mostly in their biological activities. This study focused on the synthesis and characterization of aspirinthiourea derivatives. The syntheses have been done via the reaction of acetylsalicyloyl chloride with series of amines. The long chains of amine formed by using 4-hydroxyl acetanilide and a series of bromoalkane have been synthesized. The synthesis aspirinthiourea derivatives were characterized by Fourier transform infrared spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR) and 1H NMR spectroscopy. The antibacterial properties of the synthesized compound were determined by disc diffusion method against Escherichia Coli (E.coli). However, the newly synthesized aspirin-thiourea derivatives show intermediate antibacterial activity against E.coli. The effect of the structure of the compounds on antibacterial activity is discussed.

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2015.
Uncontrolled Keywords: unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, research, Universiti Malaysia Sarawak, Thiourea, acetylsalicyloyl chloride, 4-hydroxyl acetanilide, antibacterial properties
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Faculties, Institutes, Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 21 Mar 2016 07:42
Last Modified: 20 Jan 2023 08:04
URI: http://ir.unimas.my/id/eprint/11049

Actions (For repository members only: login required)

View Item View Item
UNIMAS Institutional Repository is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.